Yes, obesity can be reversed. Negative caloric balance (caloric needs are estimated as per body weight and daily physical activity) will certainly induce weight loss in obese people. Hence, life style change is critical to reverse obesity. Various drugs developed for weight reduction, in general, have not been successful in medical practice. Bariatric surgery is gaining acceptance as a strategy to reduce morbid obesity. Extreme dietary practices like keto diet or low-carb diet or high protein diet are not recommended on long term basis. Balance diet with negative caloric intake is the most preferred option.